The SUPT16H antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to SUPT16H, and SUPT6H. This antibody recognizes Homo Sapiens, Human, and Mouse antigen. The SUPT16H antibody has been validated for the following applications: EIA, Immunoassay, Precipitation, ELISA, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2(casein kinase II)